Research

Scientists Forge Functional Human Brain Tissue Using 3D Printing

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In a remarkable leap forward for neuroscience, researchers at the University of Wisconsin–Madison have accomplished a feat previously deemed science fiction: the creation of functional human brain tissue using 3D printing technology. Led by Professor Su-Chun Zhang, this groundbreaking achievement offers profound insights into the complexities of the human brain and its associated disorders.

Published in the journal Cell Stem Cell, the study details a novel 3D-printing technique that utilizes a softer “bio-ink” gel and a horizontal layering approach. Unlike traditional vertical stacking methods, this innovative approach allows for precise control over cell types and arrangements, facilitating the development of intricate neural networks within the printed tissue. The implications of this research are staggering. By replicating the communication and network formations found in the human brain, scientists can now study neurological and neurodevelopmental disorders with unprecedented accuracy. Conditions like Alzheimer’s and Parkinson’s, which have long eluded effective treatment methods, may soon face new insights and potential therapeutic avenues.

The implications of this research are staggering. By replicating the communication and network formations found in the human brain, scientists can now study neurological and neurodevelopmental disorders with unprecedented accuracy. Conditions like Alzheimer’s and Parkinson’s, which have long eluded effective treatment methods, may soon face new insights and potential therapeutic avenues. One of the most striking aspects of the study is the ability to print various brain regions, including the cerebral cortex and the striatum, and observe interactions between different types of neurons. Professor Zhang highlights the significance of these findings, emphasizing how this model could revolutionize our understanding of human brain function.

The researchers aim to refine their bio-ink and printing equipment to create specific orientations of cells within the tissue. This advancement could lead to transformative breakthroughs in drug testing, brain development studies, and disease understanding. Moreover, the technology’s accessibility to other labs promises a wave of collaborative research in the field of neuroscience. Supported by a diverse array of funding sources, including NIH-NINDS, NICHD, and various Singaporean agencies, this pioneering research underscores the power of interdisciplinary collaboration in advancing scientific knowledge and improving human health.

The creation of 3D-printed human brain tissue represents a monumental achievement in neuroscience. As scientists continue to push the boundaries of what is possible, we stand on the brink of a new era in understanding the complexities of the human brain and unlocking novel approaches to treating neurological disorders.

Ryan General. . Scientists 3D print functional human brain tissue for first time.

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UW’s Cutting-Edge Startups: Biotech to 3D Printing

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The University of Washington has long been a nest of innovation, consistently churning out groundbreaking research that sparks the creation of pioneering startups. In this blog post, we’ll take a closer look at seven of the most recent startups to emerge from UW research, spanning the realms of biotech and 3D printing.

Apertur (Seattle): Leveraging smartphone technology, Apertur aims to revolutionize neurological disorder diagnosis by measuring pupil responses to light. Developed in collaboration with UW Medicine, this innovative device has the potential to reshape the way we identify and treat neurological conditions.

Axxis Bio (Seattle): With a focus on cancer therapy, Axxis Bio is developing a novel drug based on a molecule designed to mimic interleukin-21 (IL-21). Led by researchers from UW’s Institute for Protein Design, this startup holds promise in advancing precision medicine for cancer treatment.

Histone Therapeutics: At the forefront of precision epigenetic reprogramming, Histone Therapeutics is pioneering new approaches to enhance cell function and treat disease through gene regulation. With a groundbreaking protein developed by UW biochemists, this startup is poised to revolutionize molecular biology.

Kinea Bio (Seattle): Specializing in gene therapy for neuromuscular diseases, Kinea Bio is developing next-generation treatments based on adeno-associated viruses (AAVs). With advanced technologies and patient-focused strategies, this startup holds the potential to address unmet medical needs in neuromuscular disorders.

Myosana (Seattle): Focused on non-viral gene therapy, Myosana is developing targeted treatments for neuromuscular and cardiac genetic diseases. With a platform designed to overcome the limitations of viral delivery, this startup aims to improve outcomes for patients facing genetic disorders.

TopoGene (Seattle): Pioneering high-resolution DNA arrays for spatial omics, TopoGene is advancing spatial transcriptomics and biomolecule mapping technologies. With innovative solutions developed by UW biochemist Liangcai Gu, this startup is set to transform biological tissue analysis.

Polyfos (Israel): Tackling climate change and supply chain disruptions, Polyfos is revolutionizing additive manufacturing with multi-material 3D printing technology. Developed by former UW chemist AJ Boydston, this startup’s innovative approach promises to optimize various industries.

These seven startups represent the cutting-edge innovation emerging from the University of Washington, showcasing the transformative potential of academic research in driving entrepreneurial endeavors forward. As they continue to develop and grow, these startups are poised to significantly contribute to their respective fields and shape the future of technology and healthcare.

By on From biotech to 3D printing, here are 7 startups that recently spun out of the Univ. of Washington.

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