As reported by Experimental Eye Research, ” how stem cells (human corneal stromal cells) from a healthy donor cornea were mixed together with alginate and collagen to create a solution that could be printed, a ‘bio-ink’.
Using a simple low-cost 3D bio-printer, the bio-ink was successfully extruded in concentric circles to form the shape of a human cornea. It took less than 10 minutes to print.”
On the authority of Che Connon, Professor of Tissue Engineering at Newcastle University, who led the work, “Many teams across the world have been chasing the ideal bio-ink to make this process feasible.
Our unique gel – a combination of alginate and collagen – keeps the stem cells alive whilst producing a material which is stiff enough to hold its shape but soft enough to be squeezed out the nozzle of a 3D printer.
This builds upon our previous work in which we kept cells alive for weeks at room temperature within a similar hydrogel. Now we have a ready to use bio-ink containing stem cells allowing users to start printing tissues without having to worry about growing the cells separately.”
According to Sam Davies, “We are developing a new wave of solutions that have the potential to transform how we heal injury and disease.”
According to Tamer Mohamed, CEO, Aspect Biosystems, “We are thrilled to close this important institutional financing round with a group of world-class investors who believe in our bold vision. This funding speaks to the power of our technology and strategy in addressing multiple applications in therapeutic discovery and regenerative medicine, and will allow us to accelerate internal innovation and expand our global partnerships. With our technology platform, interdisciplinary team of scientists and engineers, and leading collaborators, we are developing a new wave of solutions that have the potential to transform how we heal injury and disease.”
According to Jordan Jacobs, managing partner, Radical Ventures, “We are very excited to partner with the excellent Aspect team to support the growth of their world-leading 3D bioprinting platform and the development of breakthrough technologies aimed at radically transforming human health.
In the opinion of Lead author and Ph.D. candidate from RMIT University’s School of Engineering, Carmelo Todaro, “the promising results could inspire new forms of additive manufacturing.
If you look at the microscopic structure of 3-D printed alloys, they’re often made up of large and elongated crystals.
This can make them less acceptable for engineering applications due to their lower mechanical performance and increased tendency to crack during printing.
But the microscopic structure of the alloys we applied ultrasound to during printing looked markedly different: the alloy crystals were very fine and fully equiaxed, meaning they had formed equally in all directions throughout the entire printed metal part.”