3D Print University
According to Uniformed Services University and NASA, “Using 3D biological printers to produce usable human organs has long been a dream of scientists and doctors around the globe. However, printing the tiny, complex structures found inside human organs, such as capillary structures, has proven difficult to accomplish in Earth’s gravity environment. To overcome this challenge, Techshot designed its BioFabrication Facility (BFF) to print organ-like tissues in microgravity, acting as a stepping stone in a long-term plan to manufacture whole human organs in space using refined biological 3D printing techniques.”
According to Nanoscribe, “Scientists and engineers at the Fundación Markoptic in Culiacán, Mexico and the Universidad Nacional Autónoma de México (UNAM), Mexico City, have fabricated a novel device that could reduce the effects of glaucoma. They used Nanoscribe’s 3D printer to create a complex microvalve that is only 300 µm in diameter.”
According to BIOLIFE4D, “We have developed a proprietary bioink using a very specific composition of different extracellular matrix compounds that closely replicate the properties of the mammalian heart. Further, it has developed a novel and unique bioprinting algorithm, consisting of printing parameters optimized for the whole heart. Coupling its proprietary bioink with patient-derived cardiomyocytes and its enabling bioprinting technology, BIOLIFE4D is able to bioprint a heart that, while smaller in size, replicates many of the features of a human heart. With this platform technology in place, BIOLIFE4D is now well-positioned to build upon this platform and work towards the development of a full-scale human heart.”
According to the Wyss Institute for Biologically Inspired Engineering at Harvard University, John A. Paulson School of Engineering and Applied Sciences (SEAS) and co-first author Mark Skylar-Scott, Ph.D., a Research Associate at the Wyss Institute, “This is an entirely new paradigm for tissue fabrication. Rather than trying to 3D-print an entire organ’s worth of cells, SWIFT (sacrificial writing into functional tissue) )focuses on only printing the vessels necessary to support a living tissue construct that contains large quantities of OBBs, which may ultimately be used therapeutically to repair and replace human organs with lab-grown versions containing patients’ own cells.”
A 3D-printed transparent skull implant.
According to Suhasa Kodandaramaiah, Ph.D., a co-author of the study and University of Minnesota Benjamin Mayhugh Assistant Professor of Mechanical Engineering in the College of Science and Engineering “What we are trying to do is to see if we can visualize and interact with large parts of the mouse brain surface, called the cortex, over long periods of time. This will give us new information about how the human brain works. This technology allows us to see most of the cortex in action with unprecedented control and precision while stimulating certain parts of the brain.”
According to Kodandaramaiah and Ebner, the research team was led by fourth-year mechanical engineering Ph.D. student Leila Ghanbari. The research team included several post-doctoral associates, graduate students and undergraduate students including Russell E. Carter (neuroscience), Matthew L. Rynes (biomedical engineering), Judith Dominguez (mechanical engineering), Gang Chen (neuroscience), Anant Naik (biomedical engineering), Jia Hu (biomedical engineering), Lenora Haltom (mechanical engineering), Nahom Mossazghi (neuroscience), Madelyn M. Gray (neuroscience) and Sarah L. West (neuroscience). The team also included partners at the University of Wisconsin including researcher Kevin W. Eliceiri and graduate student Md Abdul Kader Sagar, “This new device allows us to look at the brain activity at the smallest level zooming in on specific neurons while getting a big-picture view of a large part of the brain surface over time. Developing the device and showing that it works is just the beginning of what we will be able to do to advance brain research.”