UCSF Researchers 3D Print Human Tissues Using DNA Programming

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UCSF Researchers 3D Print Human Tissues Using DNA Programming

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Researchers at UCSF have developed a technique to build tiny models of human tissue called organoids.  The technique uses DNA to guide the assembly of cells into organoids. This technique is called DNA Programmed Assembly of Cells (DPAC.)  The research team created several organoid arrays mimicking human tissues such as mammary glands.  The research was published in the journal Nature Methods on Aug. 31, 2015.

This technique incubates cells with snippets of single strands of DNA  The DNA attaches to the cell’s outer membrane.  The incubated cell attaches to other cells that are incubated with  matching DNA strands.  In other words, the cell doesn’t attach with other incubated cells if their DNA sequence does not match. A cell can be incubated with more than one type of DNA cells.  This allows the cell to attach to different types of cells.  This technique is similar to playing with legos.  A lego piece can attach to other lego pieces if they have matching sides.  This simple trick allows lego pieces to be combined to build a very large variety of toys.  Similarly, DPAC uses DNA strands attached to cells to create different types of organoids.

This technique can be used for therapeutic drug screening.  According to Professor Gartner of UCSF, “One potential application would be that within the next couple of years, we could be taking samples of different components of a cancer patient’s mammary gland and building a model of their tissue to use as a personalized drug screening platform. Another is to use the rules of tissue growth we learn with these models to one day grow complete organs.”

https://www.ucsf.edu/news/2015/08/131431/dna-guided-3-d-printing-human-tissue-unveiled

 

https://www.ucsf.edu/news/2015/09/131716/building-human-breast-tissue-cell-cell

 

 

http://www.kurzweilai.net/dna-guided-3-d-printing-of-human-tissue

 

http://www.medgadget.com/2015/09/3d-tissue-printing-using-dna-guidance-system.html

 

http://www.healthline.com/health-news/researchers-discover-way-to-print-out-human-tissue-090715

 

http://www.nature.com/nmeth/journal/v12/n10/full/nmeth.3553.html

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2 thoughts on “UCSF Researchers 3D Print Human Tissues Using DNA Programming

    babl responded:
    December 1, 2016 at 3:23 am

    Thank for reading my post. 🙂

    Malctg - The Foureyed Poet. said:
    November 30, 2016 at 3:30 pm

    Hi babl There are many goods applications but I am sure there are far more sinister ones! Thank you for liking my poem “Communication!” Best Wishes. #TheFoureyedPoet.

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